of April 4 , 2017 . This information is current as Costimulation , and Signal 3 Cytokine Prolonged Exposure to Antigen , Development of Effector Function Require CD 8 T Cell Clonal Expansion and Mescher

Prolonged Exposure to Antigen , Development of Effector Function Require CD 8 T Cell Clonal Expansion and Mescher Julie

IL-21 promotes differentiation of naive CD8 T cells to a unique effector phenotype.

IL-21, the most recently described member of the common gamma-chain cytokine family, is produced by activated CD4 T cells, whereas CD8 T cells express the IL-21 receptor. To investigate a possible role for IL-21 in the priming of naive CD8 T cells, we examined responses of highly purified naive OT-I CD8 T cells to artificial APCs displaying Ag and B7-1 on their surface. We found that IL-21 enha...

Signal 3 Determines Tolerance versus Full Activation of Naive CD8 T Cells

Activation of naive CD8 T cells to undergo clonal expansion and develop effector function requires three signals: (a) Ag, (b) costimulation, and (c) IL-12 or adjuvant. The requirement for the third signal to stimulate Ag-dependent proliferation is variable, making the greatest contribution when Ag levels are low. At high Ag levels, extensive proliferation can occur in vitro or in vivo in the ab...

of June 15 , 2017 . This information is current as Phosphatidylinositol 3 - Kinase Activity Cell Proliferation Requires T + LFA - 1 - Mediated Costimulation of CD 8

Expression of CD80 and CD86 on T lymphocytes and monocytes of asthmatic children

INTRODUCTION The concept of costimulation has changed the way of understanding how T cells recognise and respond to antigens . The current model of T cell activation requires two signals: Signal 1: It is only an initiation event. It requires T cell receptor recognition and binding to antigen presented by antigen presenting cells. However this signal alone is necessary but not sufficient to indu...